两年的PROACTIVE-HF试验结果由LVEF分层进行了分层
Jason L Guichard1, Eric L Bonno1, Michael E Nassif2
1Department of Medicine, Division of Cardiology, Section for Advanced Heart Failure, Pulmonary Hypertension, and Mechanical Circulatory Support, Prisma Health-Upstate, Greenville, South Carolina, United States.
Journal of cardiac failure
|March 16, 2026
概括
使用Cordella PA传感器系统对心力衰竭 (HF) 患者的远程监测是安全有效的,长达两年. 这项技术有助于控制症状,并减少HF事件,无论射出分数 (EF).
科学领域:
- 心脏病学 心脏病学
- 医疗技术 医疗技术 医学技术
- 远程监控患者 远程监控患者
背景情况:
- 该PROACTIVE-HF试验最初评估了12个月的远程心力衰竭 (HF) 管理.
- 这种管理涉及全面的生命体征和坐着的肺动脉平均压力 (mPAP).
- 最初的12个月结果显示了安全性和低HF住院率 (HFH) 和全因死亡率 (HFH/D).
研究的目的:
- 将PROACTIVE-HF研究结果延长至2年.
- 通过射出分数 (EF) 来分层两年结果.
- 评估远程高频管理的持续安全性和有效性.
主要方法:
- 一个前性的,多中心的,开放的,单臂的试验.
- 使用CordellaTM PA压力传感器系统进行患者管理.
- 包括患有纽约心脏协会 (NYHA) 三级症状的患者,不论EF.
主要成果:
- 在24个月的时间里,每名患者的HF事件 (HFE) /D发生率为0.89,主要是由HFH驱动的.
- 患有减少EF (HFrEF) 的HF患者的HFE/D率较高 (1.0事件/患者),与保持EF (HFpEF) 的HF患者 (0.8事件/患者) 相比.
- 管理策略在不同EF组中证明了安全性和有效性.
结论:
- 使用Cordella PA传感器系统的远程管理与2年后中度至重度症状的HF患者的低事件率和改善的健康状况有关.
- 无论喷射分数如何,这些好处都是持续的.
- 综合远程监测,包括生命体征,坐着的PAP和患者报告的症状,支持高风险HF患者的持续益处.
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