相关实验视频

Updated: Mar 17, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

用于区分喘-COPD重叠的脂质生物标志物:基于LC-MS的脂质组学的见解

Sanjukta Dasgupta¹, Nilanjana Ghosh², Anindita Bhattacharya²

¹Department of Biotechnology, Center for Multidisciplinary Research & Innovations, Brainware University, Barasat, India.

Respiratory medicine

|March 16, 2026

概括

喘-COPD重叠 (ACO) 显示出明显的血清脂质变化,特别是六糖胺 (HCER),使其与喘和COPD区别开来. 这些HCER可以作为ACO诊断的潜在生物标志物,与肺功能相关.

科学领域:

肺部医学肺部医学
生物化学生物化学
代谢学代谢学代谢学

背景情况:

喘-COPD重叠 (ACO) 呈现出一个复杂的临床画面,与喘或COPD单独相比,症状严重,结果较差.
脂质代谢是肺炎和功能不可或缺的一部分,这表明它在ACO病理生理学中的作用.
识别特定的脂质生物标志物可以改善对ACO的理解和诊断.

研究的目的:

为了比较患有ACO,喘和COPD的患者的血清脂质概况.
为了识别特定的脂质标记物,可以区分ACO与喘和COPD.

主要方法:

来自ACO,喘和COPD患者的血清样本使用基于液态染色体质谱 (LC-MS) 的脂管学分析.
使用多变量和单变量统计分析来识别差异性脂质特征.
一个随机森林模型整合了临床和脂质组数据进行分类.

主要成果:

共有22个脂类和1185个脂类物种被确定.
显著的脂质配置文件将ACO与喘和COPD分开,其中六基胺 (HCER) 被显著改变.
特定的HCER (例如HCER ((d18:0/24:1) + H,HCER ((d18:0/20:0) + H) 在区分ACO方面表现出高精度,与FEV1和FEV1/FVC相反相关.

结论:

与喘和COPD相比,ACO表现出独特的血清脂质组变化,其中HCER是关键的区别特征.
已识别的HCER显示为ACO的潜在生物标志物具有前途.
为了确认这些探索性发现,需要在更大的队列中进一步验证.

关键词:

慢性慢性肺炎是一种慢性慢性肺炎,COPD是一种慢性肺炎.喘喘是一种喘-COPD重叠的情况生物标志物生物标志物差异诊断是一种差异诊断.脂质组的类型

更多相关视频

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function

Published on: April 12, 2024

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

Published on: April 13, 2010

相关概念视频

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History

COPD: Management Using Bronchodilators and Corticosteroids

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Asthma-IV: Diagnostic and Management

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.

Asthma-III: Symptoms and Complications

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma