在ENIGMA中的18个国际队列中,行为问题与大脑结构之间的维度关联
Marlene Staginnus1, Yidian Gao2, Sophie Townend1
1University of Bath, Bath, United Kingdom.
概括
行为问题 (CPs) 与年轻人的微妙大脑结构差异有关,影响表面积,厚度和体积. 这些神经解剖学变异很普遍,受到性别和年龄的影响.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 行为问题 (CPs) 连续分布,但它们的神经生物学基础,特别是维度方面,仍未得到充分探索.
- 了解CP的脑结构相关性对于开发有针对性的干预措施至关重要.
研究的目的:
- 以迄今为止最大的样本全面评估尺寸测量CP和大脑结构之间的关联.
- 调查这些关联的潜在调节者,包括性别,年龄和冷酷无情的特征.
主要方法:
- 在18个国际队伍中利用了来自14160名年轻人 (5-21岁) 的T1加权结构性MRI扫描.
- 采用ENIGMA标准化的预处理和回归模型协议来分析CP与皮层厚度,表面积和皮层下体积的关系.
- 根据性别,年龄和无情无情的特征检查了适度,并根据年龄,性别和内体积等共变量进行调整.
主要成果:
- 观察到CP与表面积,皮质厚度和杏仁/海马体积之间的广泛,小的负相关性.
- 确定性别作为一个关键的调节者,许多表面积的关联是针对男孩的,一些厚度的关联是针对女孩的.
- 发现的关联因年龄和冷酷无情的特征而异,在IQ调整后,一些发现仍然存在.
结论:
- 脑功能障碍与大脑结构的微妙但广泛的改变有关,超出了临床诊断的行为障碍.
- 发现了与皮层厚度的新相关性,这表明神经解剖学的差异不仅限于严重病例.
- 通过突出涉及的更广泛的大脑区域,这些发现有助于CP的神经认知模型.
相关概念视频
01:28Conduct Disorder
790
Conduct disorder is a complex mental health diagnosis characterized by a repetitive and persistent pattern of behavior that violates societal norms, the rights of others, or age-appropriate rules. The diagnostic criteria for conduct disorder require the presence of at least three problematic behaviors within the past 12 months, with at least one occurring in the past six months. These behaviors are grouped into four categories: aggression toward people and animals; destruction of property;...
790
01:30Biological Influences on Intelligence
642
Intelligence is often thought to be linked to brain size, but the relationship is more complex than that. While brain size does correlate modestly with some abilities, like verbal skills, the connection is weaker for others, such as spatial reasoning. Other factors, like brain structure, also play crucial roles. For instance, despite Einstein's smaller-than-average brain, his parietal cortex, which is involved in spatial reasoning, was 15% wider, suggesting that neural density might matter...
642