相关实验视频
Updated: Mar 17, 2026

08:31
Porous Silicon Microparticles for Delivery of siRNA Therapeutics
Published on: January 15, 2015
11.6K
功能化带有酸的半孔二氧化:一种新的方法来改善八二氧化的输送
Mohamad Anas Al Tahan1, Craig Russell2, Ali Al-Khattawi2
1School of Pharmacy, College of Health and Life Sciences, Aston University, Birmingham, United Kingdom; Aston Medical School, College of Health and Life Sciences, Aston University, Birmingham, United Kingdom.
International journal of pharmaceutics
|March 16, 2026
概括
通过使用酸功能化中孔状来改善口服的输送,从而提高了八类的透性. 然而,传统的透增强剂在这个模型中显示出更大的有效性.
科学领域:
- 生物材料科学 生物材料科学
- 药物运输 药物运输 药物运输
- 纳米技术纳米技术
背景情况:
- 口服的输送面临着由于肠道透性差和生物可用性低的挑战.
- 半孔二氧化纳米颗粒为药物输送应用提供高负载能力和可调节性质.
研究的目的:
- 为了研究一种酸功能化的半孔复合物的潜力,以提高口服八丁的透性.
- 为了比较这种复合物的有效性与自由基和常规透增强剂.
主要方法:
- 使用SEM和3D光成像对石英酸-半孔复合物的表征.
- 在体外使用Caco-2细胞单层的透性研究.
- 测量八氧化物运输和明显透性的量化 (Papp).
主要成果:
- 酸 - 半孔二氧化复合体显示,与自由二氧化 (0.8%) 相比,酸二氧化的运输量增加了 (2.68%).
- 复合物 (5.77*10-6厘米/秒对10-6厘米/秒) 增强了特的表面透性 (Papp).
- 像SNAC和SNAC+TPGS这样的常规增强剂显示出明显高于单独复合体的八二化物运输.
结论:
- 脂质功能化半孔二氧化显示出改善的透性的前景.
- 虽然有效,但测试的复合物比口服递送的常规透增强剂效力较低.
- 需要进一步的体内研究才能充分评估这种输送系统的治疗潜力.
更多相关视频
相关概念视频
Site-Targeted Drug Delivery Systems: Polymeric Carriers
82
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
82
Modified-Release Drug Delivery Systems: Site-Targeted
71
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
71
Modified-Release Drug Delivery Systems: Stimuli-Activated
74
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
74

