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阴茎癌中的微RNA:挑战,机遇和翻译前景

Tatiane K Furuya¹, Alexis Gm Carrasco¹, Miyuki Uno¹

¹Center for Translational Research in Oncology (LIM24), Instituto do Cancer do Estado de Sao Paulo (ICESP), Hospital das Clínicas da Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), Sao Paulo, SP, Brazil; Comprehensive Center for Precision Oncology, Universidade de Sao Paulo, São Paulo, SP, Brazil.

Critical reviews in oncology/hematology

|March 16, 2026

概括

微RNAs (miRNAs) 是阴茎癌 (PeCa) 发展的关键调节者. 需要进一步的研究来验证这些microRNAs作为诊断和治疗生物标志物,以改善PeCa管理.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学遗传学是一个

背景情况:

微RNAs (miRNAs) 是小的非编码RNAs,可以调节基因表达.
失调的miRNA表达与癌症的发展和进展有关.
阴茎癌 (PeCa) 是一种罕见但具有攻击性的恶性瘤,其中miRNAs起作用.

研究的目的:

审查目前关于miRNA参与阴茎癌的知识.
突出miRNAs作为潜在的诊断,预后和治疗生物标志物.
讨论PeCa.miRNA研究的挑战和未来方向.

主要方法:

关于PeCa中miRNA表达的研究的综合文献综述.
重点是分子机制,HPV关联,临床相关性和技术.
包括高通量测序和生物信息学分析.

主要成果:

几种miRNA在PeCa中具有差异性表达,与攻击性和HPV感染相关.
已识别的miRNA显示了与患者预后的潜在联系.
挑战包括小队列,缺乏功能验证和研究中的地理差异.

结论:

微RNA显示出作为PeCa.Ca的诊断,预后和治疗生物标志物的前景.
临床翻译需要更大的,标准化的,功能验证的研究.
整合多omics和AI可以加速生物标志物发现和个性化PeCa管理.

关键词:

生物信息学是一种生物信息学.微RNAs 是一个微型RNA.分子生物标志物分子生物标志物阴茎癌是阴茎癌的一种疾病.翻译研究是翻译研究.

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