在患有前列腺癌的男性中,健康的饮食模式和生存率
Binkai Liu1,2, Caroline Himbert2,3, Jane B Vaselkiv2
1Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Journal of the National Cancer Institute
|March 16, 2026
概括
在前列腺癌诊断后,坚持健康饮食,如替代健康饮食指数 (AHEI) 和地中海饮食 (AMED),可以提高生存率,特别是在不那么激烈的情况下. 饮食改变是幸存者护理的关键.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 前列腺癌是美国男性癌症死亡的主要原因之一.
- 大多数前列腺癌患者死于其他原因,而不是癌症本身.
- 在诊断后调查饮食等生活方式因素对于改善患者的治疗结果至关重要.
研究的目的:
- 检查前列腺癌诊断后坚持健康饮食模式与整体存活率之间的关联.
- 评估这些饮食模式与特定原因死亡率 (前列腺癌,心血管疾病,其他原因) 之间的关系.
主要方法:
- 从健康专业人员随访研究 (1986-2016) 中对6085名被诊断患有前列腺癌的男性进行分析.
- 对五种饮食模式的评估:替代健康饮食指数 (AHEI),地中海饮食 (AMED),DASH,抗胰岛素和抗炎饮食.
- 使用多变量Cox模型来估计死亡风险比率,考虑累积的诊断后饮食得分.
主要成果:
- 诊断后对AHEI和AMED的更强的坚持与所有原因死亡率显著降低有关.
- 随着AHEI的坚持增加,观察到更好的生存率,特别是在前列腺癌较少攻击性的男性中.
- AHEI的坚持显示出较低的心血管疾病 (CVD) 死亡率的趋势,但没有发现与前列腺癌特异性生存率有显著的关联.
结论:
- 在前列腺癌诊断后,坚持健康的饮食模式,特别是AHEI和AMED,与改善整体生存率有关.
- 改善饮食的好处在患有不那么侵袭性疾病的患者中更为明显.
- 饮食修改应被认为是前列腺癌幸存者护理的组成部分.
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