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脆弱状态预测了移植后尿路感染风险
Rebecca Unterborn1, Liza M Creel2, Kristine M Erlandson1
1Division of Infectious Diseases, Department of Medicine, University of Colorado, Aurora, Colorado, USA.
概括
脆弱性显著增加了移植 (KT) 接受者的尿路感染 (UTI) 的风险. 早期评估脆弱性对于管理移植后护理和预防此群体的尿路感染至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植 移植 移植 移植
- 老年病的医生 老年病的医生
- 传染性疾病 传染性疾病
背景情况:
- 尿路感染 (UTI) 是移植 (KT) 后的常见并发症.
- 脆弱性是老年人尿路感染的已知风险因素,但其对KT接受者的影响还未得到充分研究.
- 接受移植的接受者有增加的尿路感染和软弱的风险.
研究的目的:
- 调查脏移植受体的脆弱性和发生尿路感染的风险之间的关联.
- 确定脆弱状态是否会影响KT后尿路感染的发病率和时间.
主要方法:
- 对90名年龄在50岁或以上的脏移植接受者进行了回顾性图表审查.
- 在基线使用修改后的Rockwood-20脆弱性指数 (mFI) 评估脆弱性.
- 考克斯比例危险回归用于分析基于脆弱状态的累积尿路感染发生的主要结果.
主要成果:
- 37%的KT接受者至少患有1次尿路感染.
- 虚弱的KT接受者与非虚弱的接受者相比,尿路感染的风险明显更高 (HR8.13).
- 脆弱前的KT接受者也显示出尿路感染风险增加 (HR 4.51),脆弱的个体经历了较早的尿路感染发作.
结论:
- 虚弱和虚弱前期是脏移植受体中尿路感染的重要危险因素.
- 脆弱性评估应整合到KT接受者的移植后护理中.
- 需要有针对性的干预措施,以减轻脆弱和脆弱前的KT接受者的尿路感染风险.
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