[肥胖对青少年喘患者肺功能和喘控制的影响]
1Department of Respiratory, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400020, China.
Zhonghua er ke za zhi = Chinese journal of pediatrics
|March 16, 2026
概括
患有喘的儿童的肥胖与肺功能恶化和喘控制不良的风险增加有关. 女青少年可能更容易受到肥胖的影响.
科学领域:
- 儿科肺病学 儿科肺病学
- 喘研究 喘研究
- 肥胖与健康 肥胖与健康
背景情况:
- 喘影响着全世界数百万儿童.
- 肥胖症是儿童群体日益关注的一个问题.
- 肥胖,肺功能和儿童喘控制之间的相互作用需要进一步研究.
研究的目的:
- 调查肥胖和肺功能参数之间的关联.
- 为了检查肥胖症与喘儿童的微分排气氧化 (FeNO) 水平之间的关系.
- 为了确定肥胖是否影响儿科患者的喘控制.
主要方法:
- 对1108名10至18岁的喘儿童进行了回顾性队列研究.
- 患者被分为肥胖 (BMI-Z分数>2) 和非肥胖组.
- 使用混合效应模型分析肺功能 (FVC,FEV1,FEV1/FVC),FeNO和喘控制.
主要成果:
- 肥胖的喘儿童患喘控制不良的风险更高 (OR=1.40).
- 肥胖与FVC和FEV1正相关,但与FEV1/FVC比率负相关.
- 肥胖对肺功能的影响在女性青少年中更为明显.
- 在BMI-Z得分和FeNO水平之间没有发现显著的相关性.
结论:
- 喘青少年的肥胖与补偿性肺体积增加和空气流量限制有关.
- 患有喘的女性青少年可能更容易受到肥胖对肺功能的不良影响.
- 肥胖是儿童和青少年喘控制不良的重要危险因素.
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