婴儿急性淋巴细胞白血病治疗后的BCG感染
Mikhail Lemeshev1, Alexandra Laberko1,2, Larisa Shelikhova1
1Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia.
Pediatric blood & cancer
|March 16, 2026
概括
细菌卡尔梅特 - 格林感染 (BCGitis) 是患有急性淋巴细胞白血病 (ALL) 的婴儿的一种罕见并发症. 治疗BCGitis,通常与化疗或免疫复合相关,需要谨慎的抗菌疗法,特别是血造干细胞移植后的抗菌疗法.
科学领域:
- 儿科瘤学 儿科瘤学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 在结核病流行地区,Bacillus Calmette-Guérin (BCG) 疫苗是标准的.
- BCGitis是一种罕见的不良事件,通常会影响免疫力低下的人.
- 有限的数据存在于患有血液性恶性瘤的婴儿的BCGitis.
研究的目的:
- 为了研究患有急性淋巴细胞白血病 (ALL) 的婴儿的BCGitis.
- 描述该群体中BCGitis的临床特征,管理和结果.
主要方法:
- 在儿童瘤中心对五例BCGitis婴儿病例进行了回顾性分析.
- 对临床数据,治疗时间,免疫参数和结果的审查.
主要成果:
- BCG炎发生在患有ALL的婴儿中 (平均年龄为1.5个月),通常是在化疗,免疫疗法或血造后干细胞移植 (HSCT) 期间.
- 发病与T细胞复制或治疗诱导的细胞衰减相关.
- 所有病例都通过抗菌素治疗得到解决.
结论:
- BCG炎是患有急性白血病的婴儿的一种罕见并发症,与化疗诱导的免疫缺陷或免疫复原有关.
- 局部表现是典型的,但谨慎管理至关重要,特别是HSCT后.
- 在高风险的HSCT患者中,可以考虑预防性抗菌菌疗法.
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