菌根菌状细胞伪瘤呈现为在免疫受损患者的小腿骨中的侵略性伤病
Hao Wu1, Dieter Lindskog2, William Laskin2
11Department of Pathology, Yale School of Medicine/Yale New Haven Hospital, New Haven, CT, USA.
International journal of surgical pathology
|March 16, 2026
概括
菌根杆菌状细胞伪瘤是一种罕见的骨病变,在免疫受损的个体. 诊断需要使用特殊的染料在状囊细胞中识别菌根菌.
科学领域:
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
- 组织病理学 组织病理学
背景情况:
- 菌根菌状细胞伪瘤 (MSCP) 是非典型菌根菌感染的罕见表现.
- 通常呈现为淋巴结病变在免疫受损患者.
- 作为一个孤立的侵略性病变,骨的参与非常罕见,模仿瘤状况.
研究的目的:
- 突出MSCP作为一种罕见的差异诊断,用于激进的光骨病变.
- 强调体内化学染料在免疫受损患者的诊断效用.
- 报告一种MSCP病例,呈现为孤立的小腿骨病变.
主要方法:
- 一个79岁的男性患有低血糖球蛋白血症的病例报告.
- 一个激进的Lytic-tibial损伤的活检.
- 组织病理学检查包括耐酸性齐尔-尼尔森 (AFB),修饰性耐酸性 (Fite),PAS和GMS染色.
- 在PCR检测中发现了Mycobacterium kansasii.
主要成果:
- 活检揭示了一种载有菌细菌的螺旋状细胞伪瘤,没有形成颗粒瘤.
- 使用AFB,Fite,PAS和GMS染色剂识别了真菌菌.
- 通过PCR检测证实了Mycobacterium kansasii的感染.
结论:
- 在免疫功能低下的患者中,应考虑使用MSCP,这些患者患有由螺旋状囊细胞组成的形骨病变.
- 在这个实体中没有特征性的状颗粒瘤.
- 特殊的体内化学染料对于识别细胞内生物和实现准确诊断至关重要.
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