尿路细胞因子在预测intradetrusoronabotulinumtoxin-A反应中的作用
Marina Guirguis Hanna1,2, Ashti M Shah3, Wuqi Li4
1Department of Obstetrics & Gynecology, Division of Urogynecology, Inova Health System, Falls Church, Virginia, USA.
Neurourology and urodynamics
|March 16, 2026
概括
无症状的细菌性尿症不会影响使用Onabotulinumtoxin-A治疗膀过活的反应. 高龄和特定的尿路炎症标志物影响了女性的治疗结果.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 免疫学 免疫学 免疫学
- 老年学是一门学科.
背景情况:
- 过度活跃的膀 (OAB) 影响了数百万人,Onabotulinumtoxin-A (Botox) 是一个关键的治疗方法.
- 无症状细菌尿和尿道炎症对博托克斯疗效的影响尚不清楚.
- 了解这些因素可以优化OAB管理.
研究的目的:
- 调查无症状细菌尿,尿路炎症标志物和耐火性OAB妇女对Onabotulinumtoxin-A的反应之间的关系.
- 为了比较治疗响应者和不响应者之间的这些标记物的基线差异.
主要方法:
- 75名耐火性OAB接受Onabotulinumtoxin-A注射的妇女提供了尿液样本.
- 评估了无症状细菌性尿症,并量化了12种尿动细胞因子/化学因子.
- 响应者被定义为 >11 改善尿困 inventory 简单表格.
主要成果:
- 60%的参与者对Onabotulinumtoxin-A.有反应.
- 响应者和非响应者之间无症状细菌性尿病率没有显著差异.
- 年龄较大与响应率较低有关;炎症标志物对响应产生了年龄相关的影响.
结论:
- 无症状的细菌性尿似乎不会影响onabotulinumtoxin-A对OAB的疗效.
- 年龄是治疗反应的一个重要因素,老年妇女不太可能受益.
- 尿路炎症特征,特别是MCP1和IP10,与年龄相互作用,影响治疗结果.
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