老年人营养风险指数预测多发性骨髓瘤患者的10年生存率
Kazuhito Suzuki1, Tadahiro Gunji1, Riku Nagao1,2
1Division of Clinical Oncology/Hematology, Department of internal medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-0003, Japan.
Japanese journal of clinical oncology
|March 16, 2026
概括
用老年营养风险指数 (GNRI) 衡量的主体营养状况,显著影响多发性骨髓瘤 (MM) 患者的长期存活率. 高GNRI预测更好的整体存活率,是实现MM的长期结果的关键因素.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 老年病的医生 老年病的医生
- 营养科学 营养科学
背景情况:
- 多发性骨髓瘤 (MM) 是一种血液性恶性瘤,有一部分患者的长期存活率 (LTS) 超过10年.
- 营养状况在MM患者中预测LTS的作用在很大程度上仍未被探索.
- 这项研究调查了MM中与LTS相关的临床和营养因素.
研究的目的:
- 确定与多发性骨髓瘤 (MM) 患者的长期存活 (LTS) 相关的临床和营养因素.
- 评估老年营养风险指数 (GNRI) 作为MM中LTS的预后生物标志物.
- 开发一种预后模型,用于预测MM的10年总生存期 (OS).
主要方法:
- 对163名新诊断的MM患者 (年龄<80岁) 的回顾性分析,这些患者在2009-2014年期间接受治疗.
- 使用身高,体重和血清白蛋白计算老年营养风险指数 (GNRI).
- 接收器运行特征 (ROC) 曲线分析以确定GNRI切线LTS预测;多变量分析用于预后因素.
主要成果:
- 高GNRI与较少的CRAB症状和较低的国际分期系统 (ISS) 第三阶段有关.
- 与低GNRI (27.9%) 患者相比,高GNRI患者的10年生存率 (39.6%) 较高.
- 高GNRI和缺乏早期进展性疾病 (PD) 是改善OS的显著独立预测因素,该子组的10年OS率为49.2%.
结论:
- 通过GNRI评估的宿主营养状况是多发性骨髓瘤中长期存活的重要预后因素.
- GNRI是LTS的独立预测器,可以与早期PD状态相结合,以提高预后准确度.
- 优化营养状况可能会改善MM患者的长期结果.
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