先进的母亲年龄和辅助生殖技术:结果,基因组学和现实世界的证据
C Méndez-Vidal1,2, M Fernández-Sánchez3,4, M Domínguez-Moreno5
1Institute of Biomedicine of Seville (IBIS), University Hospital Virgen del Rocío/CSIC/University of Seville, Seville, Spain.
Frontiers in reproductive health
|March 16, 2026
概括
晚年母亲和辅助生殖技术增加了怀孕的风险. 整合基因组工具和现实世界的数据可以改善风险预测和针对这些高风险怀孕的个性化护理.
科学领域:
- 生殖医学 生殖医学
- 基因组学就是基因组学.
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 先进的母亲年龄 (≥40岁) 和辅助生殖技术 (ART) 越来越普遍.
- 无论是AMA还是ART,都与产科和围产期风险的增加有关.
- 对于AMA + ART怀孕的综合影响和管理策略需要进一步调查.
研究的目的:
- 审查目前关于与晚年母亲 (AMA) 和辅助生殖技术 (ART) 相关风险的证据.
- 探索生殖基因组学和现实世界数据 (RWD) 在管理这些怀孕中的作用.
- 讨论对临床实践和指导方针制定的影响.
主要方法:
- 一个对队列研究,系统审查和元分析的叙述性审查.
- 对基因组技术的专注分析,包括载体查,外基因组测序和植入前遗传测试 (PGT-M,PGT-A).
- 包括现实世界的数据基础设施,如注册表和电子健康记录 (EHR).
主要成果:
- AMA与流产,妊娠期糖尿病,高血压疾病和不良围产结局的风险增加有关.
- 独立地,ART增加了孕前,早产,低出生体重和新生儿并发症的风险.
- 基因组工具为变种识别,遗传条件预防和人工智能辅助胚胎选择提供了潜力;RWD增强了基于人口的分析.
结论:
- 涉及晚年孕妇和辅助生殖技术的怀孕应该被管理为高风险.
- 整合基因组技术和现实世界的数据可以促进预测性,个性化的母胎医学.
- 迫切需要基于这些进展的共识指导方针.
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