关于Lacticaseibacillus rhamnosus SAL2的安全性和益生菌特性:综合基因组学和功能验证的见解
Jie Sun1, Zhixue Li1, Xinyi Lin1,2
1Key Laboratory of Screening and Control of Infectious Diseases, Quanzhou Medical College, Fujian Provincial University, Quanzhou, China.
Frontiers in microbiology
|March 16, 2026
概括
乳酸菌 rhamnosus SAL2 的安全性和益生菌特性与L. rhamnosus GG相比较,具有较强的抗氧化活性. 这种菌株由于其肠道稳定性和粘附性,具有功能性食品和微生态制剂的潜力.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 益生菌 益生菌 益生菌
背景情况:
- 综合基因组-表型框架增强了益生菌的表征和安全性评估.
- 细胞外代谢物,而不是与细胞结合的成分,是细菌抗氧化活性的关键媒介.
- 通过研究抗氧化机制,了解微生物反应性氧物种缓解的理解得到了改进.
研究的目的:
- 评估Lacticaseibacillus rhamnosus SAL2的益生菌潜力和安全性.
- 通过全基因组测序和功能分析来描述L. rhamnosus SAL2.
- 要将L. rhamnosus SAL2与参考菌株L. rhamnosus GG. GG进行比较.
主要方法:
- 全基因组测序 (Illumina/PacBio) 用于新的组装,注释和病原性评估.
- 针对L. rhamnosus GG的多维安全性和益生菌表征基准测试.
- 通过H2O2耐受性和自由基清除试验评估抗氧化能力.
主要成果:
- L. rhamnosus SAL2具有2.99 Mbp的染色体,没有等离子体;基因注释揭示了碳水化合物代谢和运输中的作用.
- 该菌株没有表现出血解活性,对抗生素敏感,胃肠道活力高,粘膜粘附强.
- L. rhamnosus SAL2表现出与L. rhamnosus GG相当的抗氧化活性,在清除自由基方面表现优越.
结论:
- L. rhamnosus SAL2具有类似于L. rhamnosus GG的安全性和益生菌特征,但具有增强的抗氧化能力.
- 这种菌株的胃肠道耐受性,粘附性和抗氧化功效支持其在功能性食品和微生态制剂中的潜在用途.
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