肠道微生物群和性结肠炎:对知识结构,研究热点和未来方向的参考资料分析
Zhen Zhang1, Xiangcheng Hu2, Yitong Ma3
1Department of General Surgery, Jinhua Central Hospital Pan'an Branch, Pan'an, Jinhua, Zhejiang, China.
本文献分析揭示了性结肠炎 (UC) 和微生物组研究的指数增长,突出了全球主要参与者和新兴的治疗前沿,如便微生物种移植 (FMT) 和基于纳米粒子的调制UC治疗.
科学领域:
- 微生物组研究的研究.
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 性结肠炎 (UC) 是一种普遍存在的免疫媒介结肠疾病,与肠道失调有关.
- 尽管进行了广泛的研究,但UC-微生物组研究中缺乏对全球趋势,合作和主题演变的系统文献分析.
研究的目的:
- 对UC微生物组研究进行全面的文献分析.
- 确定全球生产力趋势,国际合作网络,机构生产力和关键词演变.
- 确定新兴的研究前沿和研究主题的时间演变.
主要方法:
- 来自Web of Science核心集合和维度 (2004-2025) 的5879篇文章和评论的分析.
- 使用R-bibliometrix,VOSviewer和CiteSpace来可视化出版结果,协作网络和关键字演变.
- 将Lotka和Bradford的定律应用于作者和期刊的生产力,并为新兴的边界应用爆发检测算法.
主要成果:
- 年度出版物的指数式增长 (2004年为36个,预计在2024年达到819个),中国和美国是主要贡献者.
- 确定了五个加速研究前沿:便微生物种移植 (FMT),短链脂肪酸,传统中医,肠道屏障机制和基于纳米粒子的微生物种调节.
- 研究正在从描述性的微生物组概况转向机械的,精确的向干预,在"纳米粒子"和"肠道屏障"研究 (2023-2025) 中取得了显著的势头.
结论:
- UC-微生物组研究领域已经从相关研究演变为多层次的治疗调制.
- 未来的研究应该专注于标准化FMT协议,建立多样化的队列,阐明代谢物功能,并整合纳米输送系统,以优化治疗精度和持续缓解.
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