在移植患者中药物诱导的牙过度生长
Sarah Monserrat Lomelí-Martínez1,2, Melissa Martínez-Nieto3, Ruth Rodríguez-Montaño4,5
1Department of Medical and Life Sciences, Centro Universitario de la Ciénega, Universidad de Guadalajara, Ocotlán, Mexico.
Open medicine (Warsaw, Poland)
|March 16, 2026
概括
药物诱导的牙过度生长 (DIGO) 在接受免疫抑制剂如环素A的移植患者中很常见. 塔克罗利和西罗利显示较低的DIGO风险,这表明个性化治疗方案和多学科护理是关键.
科学领域:
- 药理学 药理学是指药理学的学科.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 口腔医学是指口腔医学.
背景情况:
- 接受移植的人通常需要长期的免疫抑制.
- 药物诱导的牙过度生长 (DIGO) 是与某些免疫抑制剂相关的严重口腔并发症.
- 环素A是一种常见的罪祸首,经常用于移植后护理.
研究的目的:
- 审查移植患者药物诱导的牙过度生长 (DIGO) 的科学证据.
- 专注于流行率,病原遗传机制和临床管理策略.
- 评估替代性免疫抑制剂对它们引起DIGO的风险.
主要方法:
- 科学文献的叙述性审查.
- 包括来自PubMed,Scopus和Web of Science的研究.
- 临床研究和病例报告的分析.
主要成果:
- 环素A经常与DIGO相关,特别是与通道阻断剂结合时.
- 与环素A相比,塔克罗利莫斯的DIGO发病率较低.
- 甲和西洛利木斯具有较低的风险,尽管同时使用或先前暴露于环素A可能会影响DIGO的发生.
结论:
- 管理包括优化口腔卫生,调整免疫抑制剂剂量或替代药物.
- 个性化的免疫抑制疗法和多学科的方法对于最大限度地减少DIGO的发病率和严重程度至关重要.
- 塔克罗利马斯成为潜在的有利替代品,用于降低移植患者的DIGO风险.
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