[口腔微生态对炎症性肠病发展的影响]
Kexin Wan1, Congyi Yang1, Ning Chen1
1( 100191)Peking University Health Science Center, Beijing 100191, China.
概括
这次审查证实了口腔健康和炎症性肠病 (IBD) 之间的联系. 在IBD患者中,口腔细菌失衡 (失生症) 可以通过口腔-肠轴恶化肠道炎症.
科学领域:
- 微生物组研究的研究.
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 炎症性肠病 (IBD) 包括慢性肠道炎症.
- 人们越来越认识到口腔微生物组在全身性疾病中的作用.
研究的目的:
- 系统地审查口腔微生物组与IBD之间的关联.
- 为了阐明这种口腔-肠轴连接背后的机制.
主要方法:
- 从2000年1月到2025年10月的PubMed数据库搜索时间.
- 对77个选定的文章进行了诱导性分析.
主要成果:
- 证实了口腔失调症和IBD之间的双向因果关系.
- 在IBD患者中,口腔微生物多样性减少,病原性细菌增加 (例如,Fusobacterium nucleatum).
- 口腔病原体可以迁移到肠道,破坏肠道屏障和免疫反应,加剧IBD.
结论:
- 口腔失生症通过口腔肠轴促进IBD病原体的发生.
- 限制包括小样本大小和异质性;未来的研究需要多组学和更广泛的微生物重点 (真菌,病毒).
- 了解口腔微生物群的进展可能有助于IBD诊断和治疗.
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