[糖尿病视网膜病变中微血管变化的定量评估及其与视网膜屏障损伤的关联]
Yingqing Lei1, Hongbin Lü1, Qi Zhou1
1（ 646000）Ophthalmology Department, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
概括
光学连贯断层扫描血管造影 (OCTA) 显示了糖尿病视网膜病变 (DR) 中视网膜显著的微血管变化. 非输血区区域是预测严重DR进展的关键指标.
科学领域:
- 眼科医生 眼科 眼科
- 医疗成像医学成像
- 糖尿病学 糖尿病学
背景情况:
- 糖尿病视网膜病变 (DR) 是导致视力丧失的主要原因.
- 了解视网膜微血管变化对于DR管理至关重要.
- 血液视网膜屏障 (BRB) 的破坏是DR病理学的标志.
研究的目的:
- 在使用OCTA的DR患者中量化评估视网膜微血管变化.
- 调查这些微血管变化与BRB破坏之间的关联.
- 为了确定严重DR的预测标志物.
主要方法:
- 208名2型糖尿病患者接受了OCTA.
- 测量了VEGF和ICAM-1的血清水平.
- 进行了相关性,后勤回归和ROC曲线分析.
主要成果:
- 经过OCTA,毛细血管密度和叶无血管区 (FAZ) 参数发生了显著的变化.
- FAZ区域,循环度指数和非 perfusion zone区域与VEGF和ICAM-1相关.
- 糖尿病持续时间和VEGF是严重DR的独立风险因素.
- 非 perfusion 区的区域显示了最高的预测值 (AUC = 0.879).
结论:
- 来自OCTA的指标与DR的BRB相关标志物联系在一起.
- 非输血区区域是DR中严重的视网膜微血管变化的强有力的预测因素.
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