[对口腔恶臭的微生物驱动机制和干预策略的研究进展]
Xiaodi Shang1, Zhen Wang1, Shaohua Ge1
1· （ 250012）Department of Periodontology, School and Hospital of Stomatology, Shandong University & Shandong Key Laboratory of Oral Diseases & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan 250012, China.
概括
口腔恶臭或口臭是由口腔细菌产生的挥发性硫化合物引起的. 新的治疗方法,如植物提取物和益生菌,为治疗口臭提供了比传统药物更安全的替代品.
科学领域:
- 口腔微生物学 口腔微生物学
- 生物化学 生化学
- 牙周病学 牙周病学
背景情况:
- 口腔恶臭是一种常见的疾病,主要是由口腔微生物的代谢活动引起的.
- 口腔细菌产生的挥发性硫化合物 (VSC) 是口臭的主要来源.
- 牙周炎,真菌感染,吸烟和肥胖等因素可以通过改变口腔微环境来加剧口腔恶臭.
研究的目的:
- 审查最近在预防和治疗口腔恶臭方面的研究进展.
- 为精确的口腔恶臭管理提供新的理论基础和实践指导.
- 为了突出新的,微生物学上安全的干预口腔恶臭.
主要方法:
- 关于口腔恶臭的相关研究的文献综述.
- 对产生挥发性硫化合物的微生物代谢途径的分析.
- 评估新型治疗剂,包括植物提取物,抗菌素和益生菌.
主要成果:
- 口腔细菌,特别是Fusobacterium nucleatum和Porphyromonas gingivalis,从含硫的氨基酸中产生VSCs.
- 特定的酶系统参与氨基酸的分解,导致VSC的产生.
- 新型干预措施在抑制致病细菌,破坏生物膜和平衡口腔微生物群方面显示出卓越的微生物学安全性和有效性.
结论:
- 植物提取物,抗微生物和益生菌等新型干预措施代表了预防和治疗口腔恶臭的有希望的,更安全的策略.
- 这些方法针对病原细菌和生物膜,促进更健康的口腔微生物平衡.
- 对这些新型药物的进一步研究可以导致更精确,更有效地管理口腔恶臭.
相关概念视频
01:50What is Monogastric Digestion?
77.4K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
77.4K
01:18Surface Membrane Barriers
3.3K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
3.3K
01:28Biological Methods for Microbial Control
1.2K
Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
1.2K
01:29Biofilms
1.8K
Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
1.8K
01:28Gene Regulation in Microbial Communities: Quorum Sensing
844
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
844