机器学习模型用于预测抗精神病药物的有效性和在住院精神分裂症患者的单独成本效益分析
Jiatong Zhang1, Qian Xu2, WenLong Jiang3
1College of Pharmacy, Qiqihar Medical University, Qiqihar, Heilongjiang, People's Republic of China.
Neuropsychiatric disease and treatment
|March 16, 2026
概括
一个机器学习模型准确地预测了精神分裂症患者抗精神病治疗的疗效. 里斯佩里成为最具成本效益的治疗方法,优化了患者护理和降低医疗保健费用.
科学领域:
- 精神病学和心理健康 精神病学和心理健康
- 医疗信息学 医疗信息学
- 卫生经济学 卫生经济学
背景情况:
- 精神分裂症需要长期的抗精神病治疗,患者的反应是可变的.
- 预测治疗疗效对于个性化医疗和精神分裂症护理成本管理至关重要.
研究的目的:
- 开发一种机器学习 (ML) 模型,用于预测中国精神分裂症患者的抗精神病治疗疗效.
- 从付款人的角度进行成本效益分析,以指导临床和财务决策.
主要方法:
- 来自中国一家医院的834名精神分裂症患者的回顾性队列研究.
- 构建和评估八个ML模型,其中梯度增强机 (GBM) 模型因其卓越的性能而被选中 (AUC 0.879).
- 进行了成本效益和敏感性分析,以确定最经济的治疗策略.
主要成果:
- 开发的GBM模型在预测治疗疗效方面实现了高精度 (0.836) 和回忆 (0.823).
- 创建了一个在线预测计算器,以支持临床决策.
- 里斯佩里被确定为分析的治疗方案中最具成本效益的治疗方案.
结论:
- GBM模型及其在线计算器可以为住院患者个性化精神分裂症治疗策略.
- 瑞斯氨酸表现出卓越的成本效益,有助于优化治疗计划和降低成本.
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