对初级失眠患者的大脑功能网络和皮质形态结构的研究
Xiaoyue Jin1,2,3, Xiaoyang Wang1,2, Kuihua Wang1,2,4
1900th Hospital of PLA Joint Logistic Support Force, Fuzhou, China.
Frontiers in neurology
|March 16, 2026
概括
初级失眠 (PI) 患者表现出大脑连接和结构的改变,包括功能枢纽和皮层厚度的变化. 这些神经成像发现与睡眠质量相关,为PI机制和诊断提供了洞察力.
科学领域:
- 神经成像是一种神经成像.
- 睡眠医学 睡眠医学
- 认知神经科学 认知神经科学
背景情况:
- 全球初级失眠 (PI) 患病率正在上升.
- 了解PI的神经生物学基础对于有效的诊断和治疗至关重要.
- 现有研究表明,PI患者的大脑功能和结构可能发生变化.
研究的目的:
- 通过先进的神经成像技术,研究初级失眠的神经生物学机制.
- 在PI患者中识别异常的功能网络枢纽和连接模式.
- 检查皮质形态变化及其与PI临床症状的相关性.
主要方法:
- 招募了33名PI患者和25名健康对照人进行综合评估.
- 利用基于voxel的中心度 (DC) 分析来识别功能网络枢纽.
- 采用基于表面的形态测量 (SBM) 进行皮质厚度和旋转分析.
- 通过差异激活区域进行的全脑功能连接 (FC) 分析.
主要成果:
- 试管婴儿患者在双边前/后 cingulate 圈中呈现增加的 DC,在右头顶叶中呈现减少的 DC.
- 在特定的大脑区域观察到减少的FC,包括CEN和右小脑之间的连接,以及后部DMN和叶之间的连接.
- 观察到左侧前垂体区域的皮质稀薄,高缩指数,以及右侧垂体/左侧垂体皮层的碎形尺寸下降.
结论:
- PI与功能性大脑中心 (后部DMN,CEN顶叶) 的明显异常和功能连接性降低有关.
- 在PI患者中存在显著的皮质形态变化,例如左前对面体稀薄.
- 这些神经成像生物标志物与睡眠质量相关,为PI的机制研究和临床应用提供了基础.
更多相关视频
07:03Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
Published on: July 31, 2019
7.3K
10:43Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
Published on: July 1, 2014
15.9K
相关概念视频
Sleep-Wake Cycles
3.2K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
3.2K
Management of Insomnia
761
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
761
Insomnia
567
Insomnia is a prevalent sleep disorder characterized by difficulty falling asleep, frequent awakenings during the night, and waking up too early without being able to return to sleep. People with insomnia often experience these disruptions at least three nights a week for at least one month. Chronic insomnia, which lasts for at least three months, can lead to increased anxiety, which in turn can worsen sleep difficulties, creating a cycle of sleeplessness and stress.
Multiple factors contribute...
Multiple factors contribute...
567
Functional Brain Systems: Reticular Formation
5.8K
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
5.8K
Understanding Sleep
1.8K
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
1.8K
