时间解析的NIRS的可复制性,多距离的扩散相关谱系系统:朝着非侵入性的纵向神经监测
Farah Kamar1,2, Leena N Shoemaker1,2, Saeed Samaei1,2
1Western University, Department of Medical Biophysics, London, Ontario, Canada.
Neurophotonics
|March 16, 2026
概括
每天监测大脑血流 (CBF) 和氧化是可行的使用混合trNIRS/mdDCS系统. 这项技术可以进行可靠,可重现的测量,有助于早期检测二次脑损伤.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 医疗成像医学成像
背景情况:
- 纵向监测大脑血流 (CBF),氧化 (StO2) 和大脑代谢氧率 (CMRO2),对于早期发现二次大脑损伤至关重要.
- 当前的监测方法可能缺乏频繁,可靠的测量敏感性或可行性.
研究的目的:
- 评估内部时间分辨率近红外光谱 (trNIRS) 和多距离扩散相关性光谱 (mdDCS) 系统的可复制性和可靠性,用于日常监测.
- 通过动脉压缩测试来证明系统的纵向监测能力.
主要方法:
- 每天对志愿者进行trNIRS/mdDCS测量,持续了一个星期.
- 使用变化系数 (CV) 评估可重复性,使用类内相关系数 (ICC) 评估可靠性.
- 应用了心动脉压缩来诱导CBF,StO2和CMRO2的受控变化,用于纵向评估.
主要成果:
- 光学测量表明,在采集内,采集之间和日间的可重复性 (CV <19%) 和可靠性 (ICC 0.67-0.99) 很好或很好.
- 短距离DCS显示对探头重新定位的敏感性.
- 动脉压缩可靠地降低了CBF,StO2和CMRO2,在前三周内观察到一致的结果.
结论:
- 混合型trNIRS/mdDCS系统可用于日常监测大脑生理参数.
- 该系统提供可靠和可重现的测量,支持其在临床环境中用于早期检测神经变化.
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