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手术前的Lugol溶液和Graves病的手术结果:单中心回顾性研究

Mehmet Taner Ünlü¹, Ozan Caliskan¹, Işık Çetinoğlu¹

¹General Surgery Clinic, Endocrine Surgery Department, Health Science Universty Istanbul Sisli Hamidiye Etfal Training and Research Hospital, Sarıyer, Türkiye.

Frontiers in surgery

|March 16, 2026

概括

卢戈尔溶液 (LS) 并没有显著减少患有贝兹多格雷夫斯病 (BG) 的患者手术并发症. 这项研究发现,在BG的全甲状腺切除术期间,LS对缺甲状腺症或声带没有保护作用.

科学领域:

内分泌学和代谢障碍代谢障碍
手术瘤学手术瘤学
甲状腺手术甲状腺手术

背景情况:

贝塞道格雷夫斯病 (BG) 是甲状腺功能障碍的主要原因.
卢戈尔溶液 (LS) 通常用于BG患者的手术前,以减少甲状腺激素的产生和血管性,旨在实现更安全的手术场所.
在缓解手术并发症方面,LS的有效性仍在研究中.

研究的目的:

评估Lugol溶液 (LS) 在为Basedow Graves病 (BG) 进行全甲状腺切除术的患者减少手术并发症方面的有效性.
评估手术前LS使用与诸如下巴甲状腺功能障碍和声带等结果之间的关联.

主要方法:

在2019年至2024年期间,对128名为BG进行了全甲状腺切除术的患者进行了回顾性分析.
患者被分为两组:接受手术前LS (组1) 和未接受手术前LS (组2) 的患者.
术前生化标志物的比较 (,ALP,PTH),手术时间,样本重量和术后并发症,包括副副甲状腺症和声带.

主要成果:

对于手术前的生化水平,手术时间或甲状腺样本重量,在LS和非LS组之间没有发现显著差异.
偶发性甲状腺切除术,过渡性甲状腺功能低下症,永久性甲状腺功能低下症和声带的发病率在两组之间是可比的.
虽然LS组中过渡性甲状腺功能低下症的发生率略高,但这种差异在统计学上并不显著.

结论:

在手术前的Lugol溶液 (LS) 没有显示出对手术并发症 (包括低甲状腺功能障碍和声带) 的显著保护作用,在患有Basedow-Graves病 (BG) 的患者中.
研究结果表明,LS可能不会在改善BG患者全甲状腺切除术外科结果方面提供显著的优势.
进一步的研究可能是有必要的,以探索替代的手术前策略,或在更大的前性研究中证实这些发现.

关键词:

格雷夫斯病是什么?卢高尔的解决方案地方性肠子.手术前的准备工作外科手术的结果.甲状腺切除术是指甲状腺切除术.

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