整合分子建模和纳米乳液表征用于ibuprofen
Antônio S N Aguiar1,2, Luana A F Afiune1,3, Vitória A M Silva1
1Laboratório de Novos Materiais, Universidade Evangélica de Goiás, Anápolis 75083-515, Goiás, Brazil.
ACS omega
|March 16, 2026
概括
这项研究探讨了布洛芬 (IBU) 的固态特性及其对药物输送的影响. 纳米乳液 (NE-IBU) 与标准乳液 (EM-IBU) 相比,显示出水药物的优越稳定性和制药潜力.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 物理化学 物理化学
背景情况:
- 易布洛芬 (IBU),一种常见的NSAID,面临着低水溶性和多态性挑战,影响其生物利用性.
- 了解IBU的固态特性对于优化药物输送系统至关重要.
研究的目的:
- 为了研究两个IBU多态形式的结构,电子和超分子性质.
- 评估这些特性如何影响基于乳液的药物输送系统的开发和性能.
主要方法:
- 使用希什菲尔德表面分析,分子中原子的量子理论和密度函数理论进行固态特征.
- 布洛芬乳液 (EM-IBU) 和纳米乳液 (NE-IBU) 配方的制备和表征.
- 通过质谱学进行物理化学表征,包括滴滴大小,PDI,泽塔电位,密度和药物含量.
主要成果:
- 与EM-IBU (235.4 nm) 相比,NE-IBU的颗粒大小明显较小 (31.3 nm).
- NE-IBU 呈现出较低的多分散度指数 (0.16 与 0.23) 和更负的泽塔电位 (-25.8 mV 与 -22.1 mV).
- NE-IBU的密度更高 (0.989 g cm-3),合体和pH稳定性更高,这表明其物理化学稳定性更强.
结论:
- IBU多态的物理化学特性显著影响药物输送系统的性能.
- 纳米乳液配方 (NE-IBU) 提供卓越的体稳定性和物理化学稳定性,用于疏水性药物输送.
- NE-IBU具有相当大的制药潜力,可以增强像布洛芬这样的溶解不良药物的输送.
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