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Updated: Mar 18, 2026

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在pKID域的无序αB上的-醇位移堆增加了其对KIX的性和亲和力

Carson B Cohen1, Andrew J Andrews2, Rongsheng E Wang1

  • 1Department of Chemistry, Temple University, 1901 N. 13th Street, Philadelphia, PA 19122, USA.

Synlett : accounts and rapid communications in synthetic organic chemistry
|March 16, 2026
PubMed
概括

为像pKID这样的无序蛋白质开发高亲和度连接体是困难的. 这项研究使用了分片来稳定αB螺旋,增强了与其合作伙伴KIX的结合亲和力.

关键词:
这就是KIXIX.-二醇排位反应 (FT-DR) 是一种本质上有障碍的蛋白质 (IDP)这就是PKID pKID.酸化的方法是:光化.带有的类聚合物

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