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诺里斯克2评分与痴呆症和MCI-the HUNT研究相关

Silje Kleven^1,2, Linda Ernstsen^3,4, Marte Kvello-Alme^5,6

¹Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.

Frontiers in aging neuroscience

|March 16, 2026

概括

较高的心血管疾病 (CVD) 风险得分,如NORRISK 2,与超过22年的痴呆和轻度认知障碍 (MCI) 风险增加有关. 这些关联在女性中更强,突出了认知能力下降风险的性别差异.

科学领域:

神经学神经学
心脏病学心脏病学
流行病学流行病学

背景情况:

心血管疾病 (CVD) 风险因素与认知能力下降和痴呆症有关.
综合性心血管疾病风险评分可能反映了与认知健康相关的累积心血管疾病负担.
心血管疾病风险得分和认知结果之间的长期关联,包括性别差异,需要进一步研究.

研究的目的:

检查NORRISK 2心血管疾病风险评分和随后的痴呆症和轻度认知障碍 (MCI) 之间的长期关联.
在22年内调查男性和女性之间这些关联的潜在差异.

主要方法:

利用了来自特伦德拉格健康研究 (HUNT) 的数据,这是一个纵向,基于人口的队列.
根据HUNT2 (1995-1997) 数据计算出诺瑞斯克2分数.
在HUNT4 70+ (2017-2019) 中评估了认知状态 (认知不受损,MCI,痴呆症),使用多项逻辑回归.

主要成果:

诺里斯克2评分的1%增加与男性14%的痴呆风险和女性28%的痴呆风险相关.
患MCI的风险在男性中增加了4%,在女性中增加了10%,每NORRISK 2评分增加1%.
与男性相比,女性观察到NORRISK 2评分与痴呆症和MCI之间更强的关联.

结论:

较高的NORRISK 2评分与痴呆和MCI的风险增加有关.
心血管疾病风险得分和认知能力下降之间的关联取决于性别,女性表现出更强的联系.
这些发现强调了管理心血管疾病风险因素对认知健康的重要性,特别是在女性中.

关键词:

狩猎狩猎狩猎诺里斯克 2 在线观看心血管风险分数的得分.痴呆症痴呆症是一种痴呆症.轻度的认知障碍轻度的认知障碍可以修改的风险因素.

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