阻塞性睡眠呼吸暂停与患有阻塞性高性心肌病的患者的心肌痕负担增加有关
Shengwei Wang1, Hongchang Guo1, Ke Zhang1
1Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Vascular Blood Diseases, Beijing, China.
CJC open
|March 16, 2026
概括
阻塞性睡眠呼吸暂停 (OSA) 与高缩性心肌病 (HCM) 患者中更多的心肌痕有关. 增加的OSA严重程度与较大的痕负担相关,这表明需要进一步调查OSA治疗效果.
科学领域:
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
- 医疗成像医学成像
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 在高性心肌病 (HCM) 患者中很常见.
- 晚期加多增强 (LGE) 表明心肌痕并预测HCM的不良事件.
- 在HCM中,OSA和心肌痕负担之间的关系尚不清楚.
研究的目的:
- 调查阻塞性睡眠呼吸暂停 (OSA) 与阻塞性高性心肌病 (HCM) 患者的心肌痕负担之间的关联.
主要方法:
- 对223名阻塞性HCM患者进行前性研究.
- 使用了多睡眠学和心磁共振 (CMR) 影像与LGE量化.
- 分析了与OSA严重程度 (AHI) 和临床变量相关的LGE%.
主要成果:
- 心肌痕 (LGE%) 与OSA严重程度显著增加 (p < 0.001).
- 较高的呼吸暂停-呼吸暂停指数 (AHI) 与增加的LGE%相关.
- 在对共变量进行调整后,OSA的存在和严重程度与LGE%独立相关.
结论:
- OSA的存在和严重程度与阻塞性HCM中心肌痕增加有关.
- 需要进一步的研究来确定OSA治疗是否会影响该人群的临床结果.
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