免疫疗法诱导的腺炎: sjögren综合征或新的腺炎
Shuyuan Song1,2, Zhentao Lao1,2, Ruotong Yu1,2
1Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, China.
Frontiers in immunology
|March 16, 2026
概括
免疫检查点抑制剂 (ICI) 可以在头癌患者中引起腺炎. 这种炎症是由Th17/IL-17驱动的,阻断IL-17A在临床前模型中显示出治疗前景.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 免疫检查点抑制剂 (ICI) 提高了头部和部状细胞癌 (HNSCC) 的存活率.
- 诸如腺炎之类的不良事件尚未得到充分了解.
- 确定ICI相关的状腺炎的病理和治疗目标至关重要.
研究的目的:
- 为了描述ICI相关的腺炎的临床病理特征.
- 为了阐明病原性机制.
- 为了验证IL-17A阻塞作为治疗点.
主要方法:
- 在ICI治疗前后对HNSCC患者的唾液和眼腺的功能评估.
- 唾液腺组织的组织病理学和多平台免疫类型.
- 细胞因子量化和临床前小鼠模型对IL-17A阻断的有效性.
主要成果:
- ICI治疗显著减少了唾液和水分泌.
- 组织病理学显示了淋巴细胞透,纤维化和膜损失.
- CD4+ T细胞 (Th17子集) 和IL-17A升调是关键;IL-17A阻断恢复了小鼠的唾液功能.
结论:
- 与ICI相关的腺炎是一种独特的CD4+T细胞驱动的Th17/IL-17轴炎症状况.
- 这与Sjögren综合征和IgG4相关的腺炎不同.
- IL-17轴已被验证为ICI诱导的腺炎的潜在治疗标.
更多相关视频
相关概念视频
Autoimmune Disorders
2.1K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
2.1K
Secondary Lymphoid Organs
10.1K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
10.1K
Immunodeficiency Diseases
2.7K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
2.7K
Nephrotic Syndrome I : Introduction
836
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
836
Tonsillitis I: Introduction
2.9K
Tonsillitis is inflammation of the tonsils, which are two lymphoid tissue masses at the back of the throat. This condition can cause discomfort and irritation in the throat.
Etiology
Three primary contributing factors have been identified.
Etiology
Three primary contributing factors have been identified.
2.9K
Hypersensitivity Reactions: Immune-Complex Reactions
96
Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
96


