探索阿克梅拉物种的抗菌特性:一个系统的文献综述
Ahmad Nazrun Shuid1, Siti Farah Alwani Mohd Nawi2, Siti Norsyafika Kamarudin1
1Department of Pharmacology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Jalan Hospital, Sungai Buloh, Selangor Darul Ehsan, 47000, Malaysia.
Drug design, development and therapy
|March 16, 2026
概括
来自Acmella属的植物提取物对常见病原体具有显著的抗菌活性. 需要进一步的研究来开发这些天然化合物成为抗生素耐药性感染的有效治疗方法.
科学领域:
- 药理学 药理学是指药理学的学科.
- 微生物学 微生物学
- 民族植物学 民族植物学
背景情况:
- 抗生素耐药性需要新的抗菌剂.
- 来自植物的提取物,特别是来自Acmella属的提取物,是潜在的替代品.
- 在Acmella的抗菌性证据上存在有限的合成.
研究的目的:
- 系统地审查和评估Acmella属植物提取物的抗菌性质.
- 综合Acmella对各种细菌菌株的疗效的证据.
- 为了确定未来治疗开发的研究差距.
主要方法:
- 在Scopus,PubMed和Web of Science数据库中进行系统的文献搜索.
- 纳入标准适用于111个已识别的文章,选择了14项相关研究.
- 在体外抗菌试验的分析 (MIC,MBC,扩散方法).
主要成果:
- 阿克梅拉提取物,特别是甲醇提取物,对格兰阳性 (例如,黄金) 和格兰阴性 (例如,大肠杆菌) 细菌表现出显著的活性.
- 观察到生物膜抑制,表明潜在的持久性感染.
- (Spilanthes acmella) 是研究最多的物种.
结论:
- 阿克梅拉属的提取物具有有前途的抗菌和抗菌膜特性.
- 在口腔保健和伤口护理方面存在潜在的应用.
- 进一步的体内和临床研究是治疗转化所需的.
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