从屏障到门户:纳米材料重塑瘤微环境用于治疗
Mina Xie1,2, Wanyu Sun1,2, Dongping Hu3,4,5
1First Clinical Medical College, Gansu University of Chinese Medicine, Lanzhou, Gansu, 730000, People's Republic of China.
International journal of nanomedicine
|March 16, 2026
概括
纳米技术提供了克服瘤微环境 (TME) 障碍的解决方案,增强了癌症治疗的药物输送. 本综述探讨了各种TME亚型的纳米材料策略,旨在临床转化.
科学领域:
- 在瘤学瘤学.
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
背景情况:
- 瘤微环境 (TME) 支持瘤的生长和进展.
- 由于TME的复杂性,对有效的药物输送和癌症治疗存在重大障碍.
- 需要先进的技术来克服这些TME挑战.
研究的目的:
- 系统地审查各种瘤微环境亚型的形成机制.
- 分析纳米材料在调节TME时所面临的挑战.
- 探索不同TME亚型中纳米材料的研究策略和应用前景.
主要方法:
- 文献综述侧重于瘤微环境亚型 (免疫抑制,代谢,酸性,低毒性,层状,机械,微生物,炎症性,神经).
- 分析纳米材料的特性及其与TME组件的相互作用.
- 对基于纳米材料的TME监管的当前研究策略和未来方向的审查.
主要成果:
- 关于TME亚型形成机制的详细概述.
- 确定纳米材料透和在TME中发挥作用的关键挑战.
- 针对特定的TME亚型量身定制的各种纳米材料应用的概述.
结论:
- 纳米技术由于其独特的特性,显示出克服TME障碍的巨大潜力.
- 有针对性的纳米材料策略对于有效调节不同的TME亚型至关重要.
- 需要进一步的研究来将纳米材料创新转化为临床癌症疗法.
相关概念视频
02:17The Tumor Microenvironment
8.1K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
8.1K
02:17The Tumor Microenvironment
3.0K
3.0K
01:27Tumor Immunotherapy
2.1K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.1K
02:49Cancer Therapies
10.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.6K
01:15Drugs that Stabilize Microtubules
2.9K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.9K
02:57Targeted Cancer Therapies
9.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
9.1K