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相关概念视频

Anatomy of the Eyeball01:20

Anatomy of the Eyeball

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The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
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Measurement of Carotenoids in Perifovea using the Macular Pigment Reflectometer
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视网膜外心率作为视网膜外心率的函数的形视网膜图.

Raymond L Warner1, Peiluo Xu2, David H Brainard3

  • 1Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA 19104, USA.

Photonics
|March 16, 2026
PubMed
概括

这项研究用自适应光学扫描激光眼镜镜检测了视网膜上的形光感受器功能. 随着视网膜异常度的增加,人口视网膜图的幅度下降,为疾病生物标志物发展提供了规范性数据.

关键词:
适应式光学适应式光学眼科成像学 眼科成像学视光光学图谱 (optoretinography) 是一种视光学图谱.

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In Vivo Methods to Assess Retinal Ganglion Cell and Optic Nerve Function and Structure in Large Animals
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相关实验视频

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科学领域:

  • 眼科医生 眼科 眼科
  • 神经科学是一个神经科学.
  • 生物医学工程 生物医学工程

背景情况:

  • 适应光学扫描激光眼镜镜 (AOSLO) 能够对活着的视网膜进行面对面的成像.
  • 光网光学 (ORG) 通过测量视觉刺激期间强度变化来量化形光受体功能.
  • 建立跨视网膜异常度的规范性ORG数据对于其作为疾病生物标志物的使用至关重要.

研究的目的:

  • 用于测量正常视力个体的视网膜异常度的人口光视图 (ORG) 幅度.
  • 建立具有规范性的视网膜学数据,以便在视网膜疾病中作为生物标记物的潜在使用.
  • 为了研究ORG振幅和外视网膜厚度之间的关系.

主要方法:

  • 使用一个定制的自适应光学扫描激光眼镜 (AOSLO).
  • 测量了光视网图 (ORG) 幅度,在视网膜异心率的~1°乘以1°的位点.
  • 来自多个的聚合信号来导出人口ORG幅度.
  • 与视网膜外部厚度相关的ORG振幅,通过光学连贯断层扫描 (OCT) 测量.

主要成果:

  • 在所有参与者中,随着视网膜异常度的增加,平均人口ORG振幅显著下降.
  • 观察到ORG振幅下降模式的个体变化.
  • ORG振幅与外视网膜厚度呈正相关性,该厚度也随着离心率的下降而下降.

结论:

  • 将人口形ORG描述为异常度的函数,提供了必要的规范性数据.
  • 这些规范性数据是利用视网膜学作为视网膜疾病中光受体功能生物标志物的关键一步.
  • 与OCT测量的相关性支持这些发现的功能意义.