在接受免疫调节剂治疗的牛皮患者中,牛皮关节炎的比较风险
Madelyn Schmidt1, Travis S Dowdle2, Georgiy Golovko3
1School of Medicine, University of Texas Medical Branch, Galveston, Texas, USA.
概括
干白素-23 (IL-23) 抑制剂,如瑞桑基祖马布,古塞尔库马布和乌斯特基努马布显著降低了牛皮患者患牛皮关节炎 (PsA) 的风险. 这些发现为管理PsA进展提供了新的治疗考虑.
科学领域:
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
- 类风湿病学 类风湿病学
背景情况:
- 牛皮关节炎 (PsA) 是一种渐进的疾病,难以管理.
- 在接受特定免疫调节剂治疗的牛皮患者中,患PsA的比较风险尚不清楚.
研究的目的:
- 在接受针对IL-12,IL-17,IL-23,TNF-alpha,JAK1和JAK3.3的免疫调节治疗的牛皮患者中,评估PsA发展的3年风险.
- 为了比较不同免疫调节剂在预防PsA发作的有效性.
主要方法:
- 利用TriNetX研究网络识别被诊断患有牛皮的患者.
- 分析了从处方免疫调节剂的患者那里获得的数据,包括阿达利穆马布,埃坦塞普特,古塞尔库马布,因弗利西穆马布,伊克齐祖马布,里桑基祖马布,塞库金乌马布,蒂尔德拉基祖马布,乌斯特基努马布和科尔多利祖马布.
- 在3年的时间内评估了PsA的发病率.
主要成果:
- 干白素-23 (IL-23) 抑制剂,特别是瑞桑基祖马布,古塞尔库马布和乌斯特基努马布,在患上牛皮关节炎的风险中显示出最显著的降低.
- 其他免疫调节剂在不同程度上降低了PsA的风险.
结论:
- 瑞桑基祖马布,古塞尔库马布和乌斯特基努马布是建议的治疗选择,可用于患有牛皮的牛皮患者.
- 这些IL-23抑制剂可以帮助减轻PsA的进展并提高患者的生活质量.
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