青少年异常性关节炎的怀孕结果:系统性审查和元分析
Nattanicha Chaisrimaneepan1, Tulaton Sodsri2, Natnicha Jakramonpreeya2
1Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.
概括
患有青春性异常性关节炎 (JIA) 的女性面临几个妊娠并发症的风险增加,包括孕前,剖腹产和早产. 这项研究强调了与怀孕期间的JIA相关的关键孕产妇和新生儿风险.
科学领域:
- 风湿病学和免疫学
- 产科和妇科 产科和妇科
- 围产儿医学 围产儿医学
背景情况:
- 青春期异常性关节炎 (JIA) 是一种慢性自身免疫性疾病,影响儿童.
- 由于潜在的孕产妇和胎儿风险,JIA对妊娠结果的影响需要全面调查.
研究的目的:
- 系统地审查和元分析青少年异常性关节炎 (JIA) 与各种妊娠结果之间的关联.
- 量化患有JIA的孕妇出现不良孕产妇和新生儿并发症的风险.
主要方法:
- 在主要数据库 (PubMed,Embase,Scopus,Web of Science) 进行了全面的文献搜索,截至2025年1月.
- 包括观察性研究,比较患有和没有JIA的妇女的怀孕结果.
- 使用随机效应模型计算了聚合风险比率 (RR) 和95%置信区间 (CI).
主要成果:
- 分析包括11项研究,揭示了孕妇患有JIA的孕妇在产前/产方面风险增加 (RR 1.54),剖腹产 (RR 1.50) 和产后出血 (RR 2.12).
- 新生儿结局显示,早产的风险更高 (RR 1.74) 和对于妊娠年龄来说小 (RR 1.20).
- 没有观察到怀孕引起的高血压,妊娠期糖尿病或死产的风险显著增加.
结论:
- 青春期异常性关节炎与严重的孕产妇并发症的风险增加有关,包括妊娠前,剖腹产和产后出血.
- 患有JIA的孕妇更有可能分娩的婴儿是较小的妊娠年龄或早产.
- 这些发现强调了为患有JIA的孕妇提供专业护理的重要性.
相关概念视频
Genome-wide Association Studies-GWAS
16.5K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
16.5K
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
936
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
936
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
709
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
709
Teratogenicity
4.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.4K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
3.3K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
3.3K
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
602
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
602


