基于的NNSS双化同型双核金属循环:合成,光谱,晶体,抗癌潜力和分子对接研究
Devangana Das1, Nivas Saravanan1, Abhishek Kumar2
1Department of Chemistry, Pondicherry University Puducherry 605014 India manimaran.che@pondiuni.ac.in +91-413-2654414.
RSC advances
|March 16, 2026
概括
新的双核金属循环被合成并测试了抗癌性质. 化合物2和4对骨髓瘤和乳腺癌细胞表现出中度细胞毒性,具有针对性癌症治疗的潜力.
科学领域:
- 有机金属化学 有机金属化学
- 药用化学 医学化学
背景情况:
- 碳化合物正在探索治疗应用.
- 二氧化二胺连接体和灵活的双连接剂提供了多功能协调可能性.
研究的目的:
- 合成新的双核金属环化合物.
- 评估合成化合物的体外抗癌活性.
- 通过in silico对接研究来调查潜在的分子点.
主要方法:
- 2的反应 (CO) 10与dithioxamide连接体和灵活的双连接剂.
- 使用元素分析,FT-IR,UV-Vis,NMR光谱学和高分辨率ESI质谱学进行表征.
- 单晶X射线晶体学用于结构确定.
- 在MG-63,MCF-7和HEK-293细胞系的体外细胞毒性测定.
- 用EGFRK和MMP-9进行的in silico分子对接研究.
主要成果:
- 成功合成了四种双核金属环化合物,即[(CO) 3Mn(μ-η4-L) ((μ-L') Mn(CO) 3 (1-4),这些化合物具有双核性.
- 化合物2和4对骨肉瘤 (MG-63) 和乳腺癌 (MCF-7) 细胞表现出中度的细胞毒性.
- 化合物2和4显示有选择性的毒性,对正常的HEK-293细胞的影响较小.
- 化合物4在晶体结构分析中显示了一个类似马的框架.
- 在体研究表明,化合物4与EGFRK和MMP-9的潜在相互作用.
结论:
- 新的双核金属循环被合成并进行结构特征.
- 化合物2和4显示出针对特定癌症细胞系的有希望的抗癌潜力.
- 对作用机制和结构-活动关系的进一步研究是有必要的.
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