相关实验视频

Updated: Mar 18, 2026

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
12:52

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

16.6K

不匹配修复缺陷通过免疫抑制而不是高突变重塑质母细胞瘤

Andrew Li, Thomas K Sears, Craig M Horbinski

    The Journal of clinical investigation
    |March 16, 2026
    PubMed
    概括

    质母细胞瘤中不匹配修复缺陷不会增加瘤突变或对PD-1阻塞的反应. 相反,它促进免疫抑制,建议超越标准治疗的新治疗策略.

    更多相关视频

    Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections05:45

    Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

    Published on: July 31, 2017

    10.2K
    Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma09:17

    Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma

    Published on: September 13, 2022

    2.8K

    相关概念视频

    Mismatch Repair01:20

    Mismatch Repair

    Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
    The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
    The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
    6.9K
    Mismatch Repair01:36

    Mismatch Repair

    Overview
    44.6K
    Mismatch Repair01:36

    Mismatch Repair

    12.2K
    Abnormal Proliferation02:23

    Abnormal Proliferation

    Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
    5.4K
    Loss of Tumor Suppressor Gene Functions01:12

    Loss of Tumor Suppressor Gene Functions

    Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
    When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
    6.2K
    Loss of Tumor Suppressor Gene Functions01:12

    Loss of Tumor Suppressor Gene Functions

    2.0K