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Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
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在T细胞内在的VISTA表达通过限制CD8+T细胞反应,促进对CTLA-4阻断的抵抗

Cassandra Gilmour1, Elizabeth DeLaney1, Prerana B Parthasarathy2

  • 1Department of Translational Hematology & Oncology Research.

The Journal of clinical investigation
|March 16, 2026
PubMed
概括

从T细胞中删除V域免疫球蛋白抑制T细胞激活 (VISTA) 可以改善对瘤的初始反应,但不能提供持久的控制. 将VISTA阻塞与CTLA-4抑制相结合,可以增强T细胞功能和瘤排斥.

关键词:
适应性免疫是一种适应性免疫.癌症免疫疗法癌症免疫疗法细胞免疫反应的细胞免疫反应.免疫学 免疫学 免疫学在瘤学瘤学.

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