人类的短期睡眠限制会改变白天循环的代谢物概况,包括微生物来源的代谢物
Vanessa A Leone1, Katya Frazier2,3, Manpreet Kaur1
1Department of Animal & Dairy Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.
The Journal of clinical investigation
|March 16, 2026
概括
短期的睡眠限制会改变人体血液中的微生物代谢物的日常节奏,即使饭菜是一致的. 这表明睡眠模式和肠道微生物活动之间存在联系,这可能会对健康产生影响.
科学领域:
- 人类新陈代谢和微生物组研究
- 时间生物学和睡眠科学.
背景情况:
- 肠道微生物及其代谢产物影响宿主代谢,并表现出与睡眠和饮食有关的日常节奏.
- 睡眠不足会影响循环代谢,但其对微生物代谢物的影响尚不清楚.
研究的目的:
- 调查短期睡眠限制如何影响循环中的代谢物,包括微生物来源的代谢物的24小时概况.
- 为了确定睡眠不足是否会扰乱人类血液中微生物代谢物的昼间节律.
主要方法:
- 健康的成年人接受了一项随机交叉研究,两次24小时采血:一次是在正常睡眠 (8.5小时) 后,一次是在睡眠限制 (4.5小时) 后.
- 饮食时间,成分和热量摄入量在各种条件下均标准化.
- 血清代谢物使用非向液体染色体质谱分析;节律性使用JTK_CYCLE分析进行评估.
主要成果:
- 确定了90种代谢物,包括14种微生物来源或微生物产品 (例如,丁酸盐,酸衍生物) 的代谢物.
- 睡眠限制显著改变了整体血清代谢物组成,并扰乱了几种关键化合物的白天节律,特别是微生物代谢物,如丁酸盐和英多尔-3-酸.
- 对于金氨酸和脂质代谢中间体,出现了新的节奏,而其他节奏在睡眠限制下消失了.
结论:
- 微生物代谢物在人体血液中可检测,并表现出依赖于睡眠的昼间节律.
- 睡眠限制会扰乱这些代谢器的节奏,即使控制食物摄入量,强调睡眠和肠道微生物代谢之间的联系.
- 微生物代谢产物可以作为与睡眠不足相关的健康风险的生物标志物或媒介.
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