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自闭症谱系障碍中的执行功能障碍与大脑-小脑休息状态功能连接的增加有关

Xiaotong Zhang¹, Guorong Qiu¹, Zhiwei Mou²

¹Department of Rehabilitation Medicine, The First People's Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), School of Medicine, Southern University of Science and Technology, Guangdong, China, fshospital.org.cn.

Neural plasticity

|March 16, 2026

概括

自闭症谱系障碍 (ASD) 显示了大脑连接的改变,特别是在大脑-小脑电路中,影响了像认知灵活性这样的执行功能. 这些发现突出了小脑在自闭症执行功能缺陷中的作用.

科学领域:

神经科学是一个神经科学.
发育神经科学的发展神经科学.
认知神经科学认知神经科学

背景情况:

自闭症谱系障碍 (ASD) 的特点是社会沟通缺陷和限制性,重复性的行为.
执行功能 (EF) 在患有自闭症的个体中经常受到损害.
人们越来越认识到小脑在认知功能 (包括EF) 中的作用.

研究的目的:

研究ASD个体中小脑功能状态和执行功能 (EF) 评分之间的相关性.
探索与典型发育 (TD) 个体相比,ASD中脑小脑电路内的功能连接 (FC) 的变化.

主要方法:

使用了自闭症脑成像数据交换II (ABIDE II) 数据集.
包括71名ASD和149名TD个体,具有完整的小脑fMRI数据和EF (BRIEF) 的行为评级清单得分.
量化小谷内在活性 (PerAF) 和评估以种子为基础的FC在预定义的小谷感兴趣区域 (ROI).

主要成果:

在ASD和TD组之间没有发现小脑内在活性 (PerAF) 的显著差异.
功能连接 (FC) 分析显示,ASD患者中大脑-小脑连接主要增加.
特定小脑区域 (左侧第六叶片,左侧第I叶片) 和下额头 (IFGoper) 之间的更强的FC与较差的认知灵活性 (BRIEF Shift分数) 有积极的相关性.

结论:

小脑功能连接的改变,而不是内在活动,可能是ASD执行功能障碍的基础.
增加的大脑-小脑连接性与ASD的认知灵活性缺陷有关.
研究结果表明小脑在自闭症的EF中起着重要作用,并可能为治疗干预提供点.

关键词:

自闭症谱系障碍自闭症谱系障碍大脑 - 小脑连接性执行职能执行职能是指执行职能.静止状态功能性磁共振成像 (rs-MRI) 进行.

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