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Updated: Mar 18, 2026

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
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一个修改的甲基转移酶辅因子,可以选择性地沉默大肠杆菌中的基因表达

Oliver J Irving1, Samuel Stone1, Robert K Neely1

  • 1School of Chemistry, University of Birmingham, Birmingham, UK.

Chembiochem : a European journal of chemical biology
|March 16, 2026
PubMed
概括

在大肠杆菌中使用AdoHcy亚化物对基因表达的人工控制选择性地使基因在修饰的等离子体上失效. 这种DNA修饰抵抗了脱甲基化,为细菌基因沉默提供了新的策略.

关键词:
抗微生物耐药性 抗微生物耐药性基因沉默是对基因进行沉默的方法.甲基转移酶是一种甲基转移酶.测序的测序是指测序的测序.合成辅助因子是一种合成辅助因子.

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