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益生菌干预和认知表现:最近临床试验的见解

Bhagavathi Sundaram Sivamaruthi¹, Periyanaina Kesika¹, Chaiyavat Chaiyasut¹

¹Innovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, 50200, Thailand.

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|March 16, 2026

概括

益生菌可以通过影响肠-大脑轴来增强认知功能并对抗衰退. 特定菌株在各种条件下有望改善记忆力和情绪,尽管需要更多的研究.

科学领域:

微生物学微生物学
神经科学是一个神经科学.
胃肠病学胃肠病学

背景情况:

益生菌以其肠道健康益处而闻名,并且越来越多地研究它们对肠-大脑轴 (GBA) 的影响.
老龄化和神经精神疾病中的认知衰退给公共卫生带来了重大挑战.
GBA将肠道微生物群与大脑功能联系起来,提供治疗点.

研究的目的:

审查益生菌对认知功能干预的临床证据和机制.
评估益生菌在缓解认知衰退和增强特定人群中的大脑功能方面的作用.
突出益生菌在治疗神经退行性和精神疾病方面的潜力.

主要方法:

随机对照试验 (RCT) 和机理学研究的系统审查.
对研究研究益生菌对记忆,注意力和情绪调节的影响的分析.
检查拟议的机制,包括抗炎和神经递质调制.

主要成果:

特定的益生菌菌株 (例如,Bifidobacterium breve A1,Lactiplantibacillus plantarum P8) 在轻度认知障碍,阿尔茨海默病,抑郁症和精神分裂症中改善了认知功能.
机制包括减少炎症,抗氧化作用,神经递质平衡和改善肠道屏障完整性.
并非所有研究都显示出显著的益处,表明了菌株特异性影响和个体变异性.

结论:

益生菌显示出作为对认知健康和神经精神疾病的辅助疗法的潜力.
肠道微生物群的调节-GBA是益生菌诱导认知益处的关键机制.
进一步个性化,长期的临床试验对于优化益生菌对大脑健康的使用至关重要.

关键词:

益生菌益生菌益生菌认知障碍是一种认知障碍.肠-大脑轴肠-大脑轴神经退行. 神经退行.神经炎症是一种神经炎症.精神病生物制剂精神病生物制剂

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