突神经内置模式和肌肉纤维类型的构成,在小鼠内在的手肌的内在手肌
Chuxiang Chen1, Mingjie Zhou2, Chenpei Xu2
1Department of Hand Surgery, Huashan Hospital, National Health Commission Key Laboratory of Hand Reconstruction, Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, Institute of Hand Surgery, The National Clinical Research Center for Aging and Medicine, Department of Hand and Upper Extremity Surgery, Jing'an District Central Hospital, Fudan University, Shanghai, People's Republic of China; Department of General Surgery, Fengxian District Central Hospital, Shanghai, People's Republic of China.
这项研究绘制了老鼠手肌中的部神经内置图,在中枢神经受伤后发现了保存的运动末端板. 这些发现支持使用小鼠研究神经损伤恢复.
科学领域:
- 神经科学是一个神经科学.
- 人体解剖学 解剖学 解剖学
- 肌肉生理学 肌肉生理学
背景情况:
- 内在的手肌对于精细运动技能至关重要.
- 部神经受伤导致肌肉缩和功能丧失.
- 关于手肌内置的有限知识阻碍了有效的治疗开发.
研究的目的:
- 为了研究小鼠腰椎和骨内肌肌中腰椎神经内置的解剖基础.
- 分析这些肌肉中的肌肉纤维成分 (MHC异型).
- 建立研究小鼠部神经损伤恢复的基础.
主要方法:
- 在小鼠体内手肌的解剖学剖析和内置映射.
- 中间神经切割模型模拟神经损伤.
- 伤害后的发动机端板 (MEP) 区域的量化.
- 肌肉纤维类型的组织学分析 (MHC-I,MHC-IIa,MHC-IIb).
主要成果:
- 部神经刺激了小鼠的第三和第四腰部肌肉以及所有骨际肌肉.
- 在中枢神经切割六个月后,MEP被保留在骨内化肌肉中 (例如,第四腰椎肌肉,第三脊椎骨肌肉).
- 腰部肌肉中MHC-IIb纤维的比例较高,而背部骨肌肉中MHC-IIa纤维的比例较高.
结论:
- 这项研究澄清了老鼠内在手肌中的部神经内化模式.
- 在中枢神经损伤后的部内化肌肉中保存的MEP表明功能恢复的潜力.
- 鉴定到的解剖学和组织学特征为部神经损伤和功能恢复研究的小鼠模型提供了基础.
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