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在喉癌分期中,Ga-FAPI PET/CT 与F-FDG PET/CT 的诊断值为68和18

Ebuzer Kalender¹, Edanur Ekinci Yıldırım¹, Buket Eren¹

¹Gaziantep University Faculty of Medicine, Department of Nuclear Medicine, Gaziantep, Türkiye.

Molecular imaging and radionuclide therapy

|March 16, 2026

概括

-68纤维细胞激活蛋白抑制剂PET/CT (Ga-FAPI PET/CT) 在喉癌瘤和淋巴结中的吸收率高于F-氧葡萄糖PET/CT (F-FDG PET/CT). 这表明Ga-FAPI PET/CT可能会改善喉癌分期的敏感性.

科学领域:

核医学就是核医学.
在瘤学瘤学.
放射学放射学是一门学科.

背景情况:

喉癌 (LC) 的分期依赖于成像,F-氧葡萄糖正子发射断层扫描 (F-FDG PET/CT) 是标准的方法.
纤维细胞激活蛋白 (FAPI) 在各种癌症中过度表达,使FAPI向的正子发射断层扫描/计算机断层扫描 (PET/CT) 成为一个有前途的成像方法.

研究的目的:

为了比较Ga-FAPI PET/CT与F-FDG PET/CT用于喉癌分期的诊断性能.
评估Ga-FAPI PET/CT在检测喉癌患者中初级瘤和淋巴结转移的敏感性.

主要方法:

对14名喉癌患者 (13名男性,1名女性;平均年龄65岁) 的回顾性分析.
所有患者都接受了F-FDG PET/CT和Ga-FAPI PET/CT进行分期.
两个核医学医生对成像研究的独立评估,并系统地比较研究结果.

主要成果:

与F-FDG PET/CT (10.95对4.85) 相比,Ga-FAPI PET/CT在初级瘤中显示出显著更高的中位数最大标准吸收值 (SUV_max).
在3名患者中通过F-FDG PET/CT检测到的淋巴结参与 (中位数SUV_max 3.7) 也被通过Ga-FAPI PET/CT检测到在相同的患者中具有更高的SUV_max (7.9).

结论:

68Ga-FAPI PET/CT在喉癌原发性瘤和淋巴结中显示出优异的辐射追踪器吸收.
这种增强的吸收表明,与F-FDG PET/CT相比,喉癌分期的检测灵敏度有所提高.
需要对更大的队列进行进一步的前性研究来证实这些发现,并确定Ga-FAPI PET/CT的临床效用.

关键词:

喉癌是一种喉癌.68Ga-FAPI PET/CT 是一个可靠的方法.18F-FDG 关于PET/CT 的研究

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