利多卡因与尼费迪平基多式保守疗法对急性出血疾病的比较有效性:一个多中心队列研究
Michele Schiano di Visconte1, Sonia Sarnari2, Angelo Guttadauro3
1Department of General Surgery, Colorectal and Pelvic Floor Diseases Centre, "Azienda ULSS 2 "Marca Trevigiana".
与标准护理相比,使用利多卡因治疗急性出血疾病 (AHD) 的新型多式治疗方法提供更快的症状缓解和改善生活质量. 这种方法减少了对AHD患者的止痛药和紧急手术的需要.
科学领域:
- 产卵科 产卵科是指产卵科.
- 胃肠病学 胃肠病学
- 临床药理学 临床药理学
背景情况:
- 病 (HD) 显著影响生活质量.
- 目前对HD的保守治疗方法往往提供延迟或不充分的缓解.
- 这项研究比较了结构化的多式模式保守疗法与急性出血疾病 (AHD) 的标准护理.
研究的目的:
- 评估结构化多式联络治疗方案与AHD患者标准治疗方案的相对有效性.
- 评估症状改善和生活质量变化.
- 确定对救援止痛和紧急干预的需求的影响.
主要方法:
- 一个多中心的回顾性队列研究,涉及266名患有AHD的患者 (戈利希尔等级I-III或血栓化外部).
- 患者被分为三组:多式疗法与光体药物,布罗梅林和局部利多卡因 (A组);相同的口服疗法与局部尼菲迪平 (C组);和传统的保守治疗 (B组).
- 主要结局包括病症状评分 (HDSS) 和疼痛视觉模拟尺度 (VAS) 的变化.
主要成果:
- 所有治疗都改善了症状,但基于利多卡因的多式疗法 (A组) 在14天内更早,更大程度地减少了疼痛,症状负担和生活质量受损 (P<0.001).
- 组A需要的救援系统止痛剂显著减少 (8.9%对比于组B的28.9%,组C的26.9%,P<0.001) 和急诊程序更少.
- 在多模式治疗组中,观察到出血和围胀的早期解决.
结论:
- 结构化的多式保守疗法,特别是基于利多卡因的疗法,可以更快地缓解症状,并改善AHD患者的生活质量.
- 与标准的保守护理相比,这种方法减少了对紧急程序的需求.
- 需要进一步的前性研究来评估以利多卡因为中心的多式联络协议,用于AHD管理.
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