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Updated: Mar 18, 2026

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
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A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

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通过分子运动进行表型化:低亲和度可逆探针可通过单分子成像进行细胞群体的特征和分类.

Roger Riera1, Laurence W Fitzpatrick1, Simon Huet2

  • 1Department of Biomedical Engineering, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, De Zaale, Eindhoven 5612AZ, The Netherlands.

Journal of the American Chemical Society
|March 17, 2026
PubMed
概括

我们开发了一种超高分辨率的方法来分析细胞膜受体的移动性,用于功能性细胞表型. 这种技术使用新型探针来追踪活细胞中的受体,揭示了反映细胞类型差异的独特移动模式.

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Discrimination and Characterization of Heterocellular Populations Using Quantitative Imaging Techniques

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Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue

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相关概念视频

Protein Dynamics in Living Cells01:19

Protein Dynamics in Living Cells

Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...
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