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可植入的软膀机器接口用于神经性膀功能障碍

Hanfei Li^1,2,3, Shuai Wang^4,5, Qianhengyuan Yu¹

¹Neural Engineering Centre, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.

Nature communications

|March 17, 2026

概括

一个新的软膀机器接口 (BdMI) 监测和刺激膀,克服大膀膨胀的挑战. 这种可植入的装置显示出治疗神经性膀功能障碍的前景.

科学领域:

生物电子设备是生物电子设备.
生物医学工程生物医学工程
泌尿器科泌尿器科泌尿器科泌尿器科

背景情况:

神经性膀功能障碍导致严重的脏并发症,原因是膀的感觉和收缩受损.
膀的实质性同位素膨胀对开发可植入生物电子设备进行监测和电刺激构成重大障碍.
现有的技术很难适应膀体积的动态变化.

研究的目的:

开发和验证一种新的可植入软膀机器接口 (BdMI),能够与膀无集成.
为了实现实时监测和电刺激来管理神经性膀功能障碍.
为了克服膀同otropic 扩张对器件功能所造成的限制.

主要方法:

制造具有特殊伸展性 (高达800%) 的导电薄膜BdMI,无需预先拉伸基板.
阐明BdMI的伸展性机制.
在老鼠模型中进行体内验证,用于同时检测静脉压力,检测状体电肌学监测和电刺激治疗.

主要成果:

开发的BdMI在极端同位素拉伸下表现出强大的功能.
该设备成功植入了7天,有效运行.
通过BdMI进行的电刺激疗法显著降低了非自愿膀收缩的频率.

结论:

软BdMI代表了泌尿器科植入式生物电子设备的重大进步.
它提供实时生理反和基于电刺激的有效调节神经性膀.
这项技术有可能改善神经性膀病理的管理策略.

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