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神经元线粒体动力学:大脑疾病中的作用和治疗潜力

Xing-Xian Zhang¹, Jia-Min Du^1,2, Shen-Zhan Wang¹

¹Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, State Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang Key Laboratory of Neuropsychopharmacology, Zhejiang University, Hangzhou, 310058, China.

Acta pharmacologica Sinica

|March 17, 2026

概括

线粒体动力学对大脑健康至关重要. 这些过程中的不平衡导致大脑疾病,但针对它们提供了有希望的治疗策略.

科学领域:

神经科学是一个神经科学.
细胞生物学细胞生物学
生物化学生物化学

背景情况:

线粒体动力学,包括裂变,融合,运输和线粒体融合,对于神经元的恒常状态至关重要.
线粒体动态的失调越来越多地与各种脑部疾病的发病有关.

研究的目的:

综合审查控制线粒体动态的分子机制.
为了澄清线粒体动态在基本神经元功能中的作用.
为了检查被破坏的线粒体动力学对突触功能和神经元损伤在脑疾病的影响.

主要方法:

文献综述和对线粒体动力学现有研究的综合.
分析线粒体裂变,融合,运输和线粒体分裂的基础分子机制.
评估将线粒体动力学与突触传输,囊泡循环和缓冲相关的研究.
评估神经退行性和精神疾病中线粒体动力学功能障碍的证据.
对针对线粒体动态的新兴药物学和遗传治疗策略的审查.

主要成果:

线粒体动力学对神经元功能至关重要,影响突触传输,囊泡循环和缓冲.
线粒体动力学中断导致突触功能障碍和神经元损伤,导致神经退行和精神疾病.
准线粒体动力学是一个有前途的途径,用于治疗脑疾病的新型治疗干预.

结论:

线粒体动力学在维持大脑健康方面发挥着至关重要的作用.
线粒体动力学的不平衡是导致大脑疾病病理生理学的关键因素.
旨在调节线粒体动态的治疗策略具有治疗神经和精神疾病的巨大潜力.

关键词:

线粒体的动力学神经退行症的神经退行症神经元神经元是一个神经元.神经精神疾病:神经精神疾病.治疗策略是一种治疗策略.

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