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相关概念视频

Urinary Bladder01:23

Urinary Bladder

The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
Anatomy of the Genitourinary System II: Bladder and Urethra01:19

Anatomy of the Genitourinary System II: Bladder and Urethra

The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...

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相关实验视频

Updated: May 10, 2026

Urinary Tract Infection in a Small Animal Model: Transurethral Catheterization of Male and Female Mice
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Urinary Tract Infection in a Small Animal Model: Transurethral Catheterization of Male and Female Mice

Published on: December 1, 2017

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鼠标泌尿膀的空间转录图.

Nives Matković1, Andrea Gelemanović2, Kristijana Popović1

  • 1Laboratory for Cancer Research, School of Medicine, University of Split, Split, Croatia.

Scientific reports
|March 17, 2026
PubMed
概括
此摘要是机器生成的。

这项研究使用空间转录学绘制了小鼠泌尿膀的基因表达. 这些发现揭示了不同的细胞类型和逐渐的组织层过渡,增强了我们对膀生物学的理解.

关键词:
拉米纳自己的拉米纳.一只小鼠的尿膀.顺滑肌肉是指平滑的肌肉.空间转录学 空间转录学泌尿器皮质 (urothelium) 是一个细胞.

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科学领域:

  • 泌尿器科 泌尿器科 泌尿器科 泌尿器科
  • 基因组学就是基因组学.
  • 空间生物学 空间生物学

背景情况:

  • 了解膀的空间组织对于诊断和治疗膀病理至关重要.
  • 传统的组织学和单细胞RNA测序 (scRNA-seq) 方法在捕捉组织结构和细胞与细胞相互作用方面存在局限性.

研究的目的:

  • 为了创建一个高分辨率的鼠标膀的空间转录图.
  • 识别不同细胞群体及其在膀壁内的空间分布.
  • 为了揭示基因表达模式和细胞在不同膀区间的过渡.

主要方法:

  • 利用Visium HD空间转录技术在小鼠尿膀组织上.
  • 在质量过后分析了66,471个空间容器和9,364个基因.
  • 使用正规标记基因和综合参考数据集 (Tabula Muris,鼠标细胞图谱) 进行注释的细胞群.

主要成果:

  • 鉴定出13个不同的集群,对应于泌尿层,自身层和光滑肌肉层.
  • 通过组织层观察到逐渐的基因表达过渡,而不是利的边界.
  • 在尿膜内分化基底,中间和雨细胞,注意到雨细胞中潜在的mRNA极化.
  • 检测到四个不同的光滑肌群,不同于来自非空间scRNA-seq.q.的单个群.
  • 发现了 lamina propria 主要由纤维细胞和免疫细胞组成.

结论:

  • 空间转录学为膀研究中的组织学和scRNA-seq提供了一个强大的补充.
  • 生成的地图为研究小鼠泌尿膀生物学提供了宝贵的资源.
  • 这项研究为未来对膀疾病及其空间基础的研究奠定了基础.