浮动粘膜粘合剂胃保持剂片用于增强口服输送glimepiride:配方,优化和控制释放
Ankita Basak1, Soumyadip Ghosh2,3, Dharmajit Pattanayak4
1Department of Pharmaceutics, Calcutta Institute of Pharmaceutical Technology and Allied Health Sciences,Banitabla, Uluberia , 711316, India.
AAPS PharmSciTech
|March 17, 2026
概括
浮动粘膜片改善了对2型糖尿病的glimepiride (GLM) 输送. 这种新型配方增强了胃的保留和受控释放,可能会提高治疗结果.
科学领域:
- 制药技术 制药技术 制药技术
- 药物输送系统 药物输送系统
- 材料科学 材料科学 材料科学
背景情况:
- 硫氨基酸之一的格莱梅皮里德 (GLM) 面临着2型糖尿病治疗的挑战,原因是溶解性差和吸收变化.
- 这些局限性导致治疗疗效不一致,需要改进药物输送策略.
研究的目的:
- 开发和优化浮性粘膜粘合剂 (FM) 胃保持药片的glimepiride (GLM).
- 提高胃留时间,实现可控的胃内药物释放,以提高生物可用性.
主要方法:
- 为了优化聚合物组成 (HPMC K15M,Carbopol 940P) 和泡负载 (碳酸),使用了3 ^ 2的因数设计.
- 进行了物理化学表征 (FTIR,DSC),机械测试,微米分析和体外药物释放研究.
- 使用扫描电子显微镜 (SEM) 阐明药物释放机制.
主要成果:
- 优化的FM平板显示出快速浮力和持续漂浮超过24小时.
- 实验室研究表明,在Higuchi动力学 (Fickian扩散) 之后,GLM释放持续了6小时.
- 物理化学评估证实了药物辅助剂的兼容性和可接受的药片特性.
结论:
- 开发的FM胃保留系统显示了改善glimepiride口服生物可用性的潜力.
- 这种配方策略可以应用于其他需要长时间的胃保留和扩散控制释放的药物.
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