药剂师带领的缩水器与简短的正念告知认知行为疗法,用于在老年人处方佐地亚平:试点试验

相关实验视频

Updated: Mar 18, 2026

12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

8.2K

Timothy S Anderson^1,2, Kristen M Kraemer³, Marissa L McCann³

¹Division of General Internal Medicine, University of Pittsburgh, Pittsburgh, PA, USA. tsander@pitt.edu.

Journal of general internal medicine

|March 17, 2026

概括

一个虚拟程序结合药剂师主导的逐渐和认知行为疗法 (CBT) 成功降低了老年人的二使用. 这种以团队为基础的方法在初级保健机构的抑郁症处方方面具有前景.

科学领域:

老年医学老年医学
药理学药理学是指药理学的学科.
精神病学是一个精神病学.

背景情况:

长期使用二甲在老年人中很普遍,带来了显著的风险,但证明的益处有限.
迫切需要有效的,初级保健可访问的策略,以支持在这个人群中停止使用二.

研究的目的:

评估以团队为基础的虚拟干预对老年人二二类药物停止处方的可行性和可接受性.
探索以患者为中心的结果,包括二二胺剂量变化,焦虑和睡眠障碍.

主要方法:

一个单臂前性试验,涉及65岁以上的成年人长期服用二.
一个为期10周的虚拟计划,包括药剂师指导的逐渐缩小和心理学家领导的正念告知认知行为疗法 (CBT).
测量结果包括入学,留住,坚持,定性反,减少二胺剂量,以及PROMIS焦虑和睡眠分数.

主要成果:

17名注册参与者的100%完成了这项研究,证明了高可行性和坚持.
实现了二二胺剂量的显著平均减少60.5%,其中3名参与者完全停止服用.
PROMIS焦虑得分显著下降 (p=0.02),而睡眠障碍得分没有显著变化.

结论:

虚拟的,以团队为基础的干预,将药剂师领导的逐渐缩小和正念的CBT整合起来,对于老年人来说是可行的和可以接受的.
这种方法显示,在初级保健环境中,有潜力减少老年人使用二二和焦虑.
进一步的多地点测试是有必要的,以验证这些有希望的发现.

关键词:

这种类型的 benzodiazepines.临床试验临床试验临床试验临床试验临床试验认知行为疗法是一种认知行为疗法.这是一个令人丧的描述.药剂师药剂师药剂师药剂师

相关概念视频

01:14

CNS Depressants: Barbiturates and Benzodiazepines

1.6K

CNS depressants include drugs from the category of barbiturates and benzodiazepines. They are valuable medications for managing anxiety disorders and insomnia. Barbiturates, once used to induce and maintain sleep, have been replaced mainly by benzodiazepines due to barbiturate's toxicity, tolerance, and overdose risks. They interact with GABAA receptors, leading to sedation at low doses and potentially coma and death at higher doses. Phenobarbital, a long-acting barbiturate, possesses...

1.6K

01:29

Anxiolytic Drugs: Benzodiazepines and Buspirone

2.9K

Benzodiazepines are a class of anxiolytic drugs known for their rapid efficacy and high therapeutic-to-lethal dose ratio, but with a potential risk of drug dependence. These drugs are lipophilic, allowing for rapid absorption after oral administration, eventually reaching the central nervous system (CNS). Once in the CNS, benzodiazepines bind to the allosteric site of the GABAA receptor. This binding enhances the inhibitory effects of the neurotransmitter GABA. By doing so, they prevent...

2.9K

01:28

Drug Therapy

376

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications

376

01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

309

01:15

Drug Dosing: Geriatric Patients

344

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

344

01:19

Sedatives and Hypnotics Drugs: Benzodiazepines

1.2K

Benzodiazepines have both sedative and hypnotic properties. They include compounds such as diazepam (Valium) and alprazolam (Xanax). Structurally, their cores are similar, consisting of the fusion of a benzene ring and a diazepine ring, but they share a common mechanism of action in the central nervous system (CNS).
Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...