概括
针对亚托皮性疾病的生物药物与非活体疫苗是安全的,尽管反应可能会减少. 新出现的数据表明,一些活体疫苗也可能是安全的,特别是在治疗dupilumab的儿科患者中,需要个性化风险效益评估.
科学领域:
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 针对2型炎症的生物疗法对亚托皮性疾病至关重要.
- 对于接种这些疗法的患者,特别是活减弱疫苗的患者,对疫苗的使用存在担忧.
- 目前的指导方针建议谨慎使用,因为实际风险的证据有限.
研究的目的:
- 审查临床关注点和疫苗接种的证据,在接受生物药物治疗阿托皮性疾病的患者.
- 为疫苗接种提供实际建议,重点关注dupilumab.
- 评估活体和非活体疫苗的安全性和有效性.
主要方法:
- 对相关研究和指导进行全面的PubMed/MEDLINE文献搜索.
- 包括随机对照试验,大型观察性研究和注册数据.
- 主要搜索词包括"生物疗法"",疫苗接种"",疫苗反应"和疫苗类型.
主要成果:
- 非活体疫苗通常是安全有效的,具有潜在的适度降低免疫反应.
- 一项试验显示,在dupilumab和安慰剂组之间,对风和脑膜炎球菌疫苗的抗体反应相似.
- 针对COVID-19疫苗的研究显示出混合的结果;活体减弱疫苗数据挑战了传统的禁忌.
结论:
- 非活体疫苗在接受生物治疗的患者中是安全有效的,用于治疗亚托皮性疾病,具有潜在的减少,但充足的免疫反应.
- 新出现的证据表明,某些活体减弱疫苗可能是安全的,特别是在儿科使用dupilumab的儿童中.
- 个性化风险效益评估对于接种疫苗的决定至关重要;对于最终的指导方针,需要进一步研究.
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